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Shelby A. Neal, MD

Shelby A. Neal, MD

Director of Assisted Reproductive Technology and Third Party Reproduction

About

Dr. Neal strives to provide top-quality care to patients who are concerned about their fertility, whether they wish to conceive now or preserve their fertility for the future.

As the Director of Assisted Reproductive Technology and Third Party Reproduction, she is happy to offer a variety of treatment options to her patients and assist them in choosing the one that is right for them.

Dr. Neal’s clinical interests include infertility, recurrent pregnancy loss and fertility preservation.

Training

  • Fellowship in Reproductive Endocrinology & Infertility, IVI/Reproductive Medicine Associates of New Jersey  Basking Ridge, NJ, 2016-2019 
  • Residency in Obstetrics & Gynecology, Medical University of South Carolina, Charleston, South Carolina, 2011-2015
  • M.D., University of North Carolina at Chapel Hill School of Medicine, 2011

Clinical Focus and Research

Dr. Neal's clinical focus is infertility, recurrent pregnancy loss and fertility preservation. Her research interests include predictors of IVF success and failure, preimplantation genetic testing and three dimensional ultrasound imaging.

Publications

Neal SA, Morin SJ, Werner MD, Gueye NA, Pirtea P, Scott Jr. RT, Goodman LR. Three-dimensional ultrasound diagnosis of T-shaped uterus is associated with adverse pregnancy outcomes following embryo transfer. Reprod Biomed Online. 2019 Nov;39(5):777-783. 

Neal SA, Sun L, Jalas C, Morin SJ, Molinaro TA, Scott Jr. RT. When next-generation sequencing-based preimplantation genetic screening testing for aneuploidy (PGT-A) yields an inconclusive report: diagnostic results and clinical outcomes after re-biopsy. J Assist Reprod Genet. 2019 Oct;36(10):2103-2109. 

Morin S, Hanson B, Juneau C, Neal S, Landis J, Scott R, Hotaling J. Comparison of the relative efficiency of ICSI and extended culture with epididymal sperm versus testicular sperm in patients with obstructive azoospermia. Asian J of Androl. 2019 Jul 2, epub ahead of print. 

Neal SA, Morin SJ, Franasiak JM, Goodman LR, Juneau CR, Forman EJ, Werner MD, Scott Jr. RT. In vitro fertilization (IVF) with preimplantation genetic testing for aneuploidy (PGT-A) is cost-effective, shortens treatment time, and reduces the risk of failed embryo transfer and clinical. Fertil Steril. 2018 Oct;110(5):896-904. 

Morin SJ, Patounakis G, Juneau CR, Neal SA, Scott RT, Seli E. Diminished ovarian reserve and poor response to stimulation in patients < 38 years old: a quantitative but not qualitative reduction in performance. Hum Reprod. 2018 33(8):1489-1498. 

Juneau CR, Franasiak JM, Goodman LR, Marin D, Scott K, Neal SA, Morin SJ, Juneau J, Scott Jr. RT. Celiac disease is not more prevalent in patients undergoing IVF and does not impact reproductive outcomes with or without treatment: a large, prospective cohort study. Fertil Steril. 2018 Aug;110(3):437-442. 

Franasiak J, Kaser D, Goodman L, Patuonakis G, Juneau C, Morin S, Neal S, Schlaff W, Scott Jr. R. Characterization of reproductive endocrinology and infertility (REI) fellowship applicants: guiding our mentees toward success. Fertil Res Pract. 2017 Dec 8;3:18. 

Rashid T, Young-Pierce JL, Garrett-Mayer E, Graybill W, Neal S, Spruill LS. CD8, FoxP3, and CD45RO+ lymphocytic infiltrates in type I and type II endometrial cancers in African American and European American females. Int J Gynecol Pathol 2017 Nov;36(6):540-549. 

Neal SA, Franasiak JM, Forman EJ, Werner MD, Tao X, Treff NR, Scott RT. High relative deoxyribonucleic acid content of trophectoderm biopsy adversely affects pregnancy outcomes. Fertil Steril 2017, Mar;107(3):731-736. 

Treff NR, Thompson K, Rafizadeh M, Chow M, Morrison L, Tao X, Garnsey H, Reda CV, Metzgar TL, Neal S, Jalas C, Scott RT Jr, Forman EJ. SNP array-based analyses of unbalanced embryos as a reference to distinguish between balanced translocation carrier and normal blastocysts. J Assist Reprod Genet 2016, Aug;33(8):1115-9. 

Neal SA, Garrett-Mayer E, Graybill WS, McDowell ML, McLean VE, Watson CH, Pierce JY, Kohler MF, Creasman WT. Lymphovascular space invasion in uterine corpus cancer: what is its prognostic significance in the absence of lymph node metastases? Gynecologic Oncology 2016, Aug;142(2):278-282. 

Addison S, Coleman R, Feng S, McDaniel G, Kraus V. Whole body bone scintigraphy provides a measure of total body burden of osteoarthritis for the purposes of systemic biomarker validation. Arthritis & Rheumatism 2009, Nov;60(11):3366-73. 

INVITED CONTRIBUTIONS 

Neal SA, Werner MD. Quest for a less invasive approach to preimplantation genetic testing remains ongoing. Fertil Steril. 2018 Oct;110(5):845-846. 

Neal SA, Werner MD. The impact of contemporary preimplantation genetic screening and diagnosis on the detection of aneuploidy and inherited genetic diseases. Birth Defects Res. 2018;110(8):644-647. 

Henrotin Y, Addison S, Kraus V, Deberg M. Type II collagen markers in osteoarthritis: what do they indicate? Curr Opin Rheumatol 2007, Sep;19(5):444-50. 

BOOK CHAPTERS 

Neal SA, Franasiak JM, Scott Jr. RT (2018). Hematologic Disease in Implantation Failure. In Franasiak JM and Scott Jr. RT (Eds.), Recurrent Implantation Failure: Etiologies and Clinical Management (pp. 125-143). Springer International Publishing. 

PRESENTATIONS AND ABSTRACTS 

Klimczak AM, Whitehead CV, Neal SA, Tiegs AW, Osman EK, Hanson BM, Kim JG, Werner MD, Franasiak JM, Scott Jr. RT. Non-invasive prenatal testing has altered positive predictive value following transfer of a euploid blastocyst. Fertil Steril 2019; 112(3)e18. 

Tiegs AW, Tao X, Whitehead CV, Neal SA, Osman EK, Kim JG, Hanson BM, Seli E, Patounakis G, Gutmann J, Castelbaum A, Scott Jr. RT. Does preimplantation genetic testing for aneuploidy (PGT-A) harm embryos? No – a multi-center, prospective, blinded, non-selection study evaluating the predictive value of an aneuploidy diagnosis and impact of biopsy. Fertil Steril 2019; 112(3)e31. 

Hanson BM, Tao X, Zhan Y, Jenkins TG, Kim JG, Osman EK, Tiegs AW, Neal SA, Scott Jr. RT, Seli E. The relationship between chronologic age, ovarian response, and DNA methylation of white blood cells and cumulus cells among infertile women undergoing IVF. Fertil Steril 2019; 112(3)e33-34. 

Neal SA, Scott Jr. RT, Goodman LR. Pregnancy outcomes following hysteroscopic correction of T-shaped uteri. Fertil Steril 2019; 112(3)e37-38. 

Neal SA, Scott Jr. RT, Goodman LR. Low endometrial volume is not associated with diminished live birth following transfer of a single thawed euploid blastocyst. Fertil Steril 2019; 112(3)e54-55. 

Hanson BM, Tao X, Zhan Y, Kim JG, Osman EK, Tiegs AW, Neal SA, Scott Jr. RT, Seli E. Shorter telomere length of white blood cells is associated with higher rates of aneuploidy in women undergoing in vitro fertilization. Fertil Steril 2019; 112(3)e76. 

Neal SA, Morin SJ, Werner MD, Gueye NA, Pirtea P, Patounakis G, Scott Jr. RT, Goodman LR. Three-dimensional ultrasound diagnosis of adenomyosis is not associated with diminished live birth following single thawed euploid blastocyst transfer: a prospective cohort study. Fertil Steril 2019; 112(3)e89. 

Hanson BM, Kim JG, Tiegs AW, Osman EK, Neal SA, Lathi RB, Scott Jr. RT, Franasiak JM. The impact of paternal age on reproductive outcomes in the setting of a euploid single embryo transfer achieved with surgically extracted sperm. Fertil Steril 2019; 112(3)e108. 

Hanson BM, Kim JG, Osman EK, Tiegs AW, Neal SA, Lathi RB, Scott Jr. RT, Franasiak JM. Increased paternal age is associated with decreased blastulation and euploid rates but not pregnancy outcomes in the setting of euploid blastocyst transfer. Fertil Steril 2019; 112(3)e142-143. 

Murugappan G, Kim JG, Kort JD, Hanson BM, Neal SA, Tiegs AW, Osman EK, Scott Jr. RT, Lathi RB. Blastocyst grade predicts outcome after frozen euploid transfer in patients with recurrent pregnancy loss. Fertil Steril 2019; 112(3)e151. 

Neal SA, Tao X, Sun L, Hanson BM, Kim JG, Osman EK, Tiegs AW, Scott Jr. RT, Franasiak JM. High concordance between vaginal and cervical microbiome assessments with increasing microbial diversity negatively impacts pregnancy outcomes following transfer of a single euploid blastocyst. Fertil Steril 2019; 112(3)e192. 

Hanson BM, Kim JG, Osman EK, Tiegs AW, Neal SA, Werner MD, Scott Jr. RT. The impact of ovarian response on clinical pregnancy and delivery rates in an oocyte donor population. Fertil Steril 2019; 112(3)e195-196. 

Kim JG, Patounakis G, Juneau CR, Franasiak JM, Morin SJ, Neal SA, Tiegs AW, Osman EK, Hanson BM, Seli E, Scott Jr. RT. ABC trial: Body mass index and percentage body fat are not different in positive predictive value of miscarriage or preterm delivery in patients undergoing IVF. Fertil Steril 2019; 112(3)e212-213. 

Osman EK, Neal SA, Tiegs AW, Hanson BM, Kim JG, Franasiak JM, Scott Jr. RT. Rates of embryonic mosaicism are consistent amongst embryologists performing or loading trophectoderm 

biopsies for preimplantation genetic testing for aneuploidy (PGT-A). Fertil Steril 2019; 112(3)e233. 

Kim JG, Hanson BM, Reig A, Neal SA, Tiegs AW, Osman EK, Bergh PA, Seli E, Scott Jr. RT. The impact of IVF on neonatal birthweight from 2000 to 2017: A dramatic reduction of low birthweight infants. Fertil Steril 2019; 112(3)e300-301. 

Tiegs AW, Neal SA, Osman EK, Kim JG, Hanson BM, Franasiak JM, Scott Jr. RT, Goodman LR. Pregnancy outcomes following intrauterine insemination (IUI) in young women with decreased ovarian reserve. Fertil Steril 2019; 112(3)e384-385. 

Kim JG, Murugappan G, Lathi RB, Kort JD, Hanson BM, Tiegs AW, Osman EK, Neal SA, Scott Jr. RT. Preimplantation genetic testing for aneuploidy (PGT-A) reduces miscarriage and improves live birth rates in recurrent pregnancy loss patients. Fertil Steril 2019; 112(3)e401. 

Merriam KS, Neal SA, Morin SJ, Tiegs AW, Landis J, Scott Jr. RT, Werner MD. Nonclassical congenital adrenal hyperplasia carriers have a higher prevalence of polycystic ovary syndrome than the general population. Fertil Steril 2019; 111(4)e45. 

Kim JG, Jalas C, Hanson BM, Tiegs AW, Osman EK, Neal SA, Scott RT Jr. Mapping of single nucleotide polymorphisms (SNPS) along a heterozgosity plot correlates with DNA copy number in comprehensive chromosome screening (CCS). Eighth international IVIRMA Congress 2019. 

Neal SA, Tiegs AW, Osman EK, Kim JG, Hanson BM, Werner MD, Scott RT Jr. When In vitro fertilization fails: is intrauterine insemination a reasonable treatment strategy? Eighth international IVIRMA Congress 2019. 

Hanson BM, Kim JG, Tiegs AW, Osman EK, Neal SA, Werner MD, Scott RT Jr. The effect of ovarian response on clinical pregnancy and delivery rates in an oocyte donor population. Eighth international IVIRMA Congress 2019. 

Tiegs AW, Sun L, Neal SA, Osman EK, Kim JG, Hanson BM, Scott RT Jr. Day 7 euploid blastocysts have reduced morphologic grades as completed with day 5 and 6 blastocysts. but satisfactory sustained implantation. Eighth international IVIRMA Congress 2019. 

Tiegs AW, Bauman B, Neal SA, Osman EK, Kim JG, Hanson BM, Scott RT Jr. Do variations exist in fertilization blastulation and sustained implantation rates by intracytoplasmic sperm injection (ICSI) operator? Eighth international IVIRMA Congress 2019. 

Osman EK, Neal SA, Tiegs AW, Kim JG, Hanson BM, Werner MD, Suns L, Franasiak JM Scott RT Jr. Embryonic aneuploidy rates in patients utilizing surgical sperm are equivalent to those utilizing ejaculated sperm for in vitro fertilization (IVF) cycles. Eighth international IVIRMA Congress 2019. 

Neal SA, Goodman LR, Morin SJ, Werner MD, Gueye NA, Tiegs AW, Pirtea P, Scott Jr. RT. T-shaped uterine cavity morphology as assessed by three-dimensional ultrasound (3D US) is associated with lower sustained implantation rates and higher clinical loss rates following frozen embryo transfer. Fertil Steril 2018;110(4)e132. 

Neal SA, Goodman LR, Morin SJ, Werner MD, Gueye NA, Tiegs AW, Pirtea P, Scott Jr. RT. Only patients with obvious adenomyosis on three-dimensional ultrasound (3D US) are at increased risk of clinical loss following frozen embryo transfer. Fertil Steril 2018;110(4)e84. 

Osman EK, Neal SA, Slowey MJ, Cook H, Schnorr JA. The role of human chorionic gonadotropin supplementation in oocyte donor ovarian stimulation. Fertil Steril 2018;110(4)e331. 

Kim JG, Morin SJ, Patounakis G, Juneau CR, Neal SA, Tiegs AW, Scott Jr. RT. ABC trial: appraisal of body content. Frozen embryo cycles are not impacted by the negative effects of obesity seen in fresh cycles. Fertil Steril 2018;110(4)e68-69. 

Parker PB, Morin SJ, Neal SA, Tiegs AW, Landis J, Scott Jr. RT, Werner MD. Inner cell mass and trophectoderm morphology impact the likelihood of achieving sustained implantation among expanded, euploid blastocysts. Fertil Steril 2018;110(4)e212-213. 

Dolitsky SN, Neal SA, Olcha M, Hong KH, Werner MD, Morin SJ, Tiegs AW, Sun L, Scott Jr. RT. Initial serum human chorionic gonadotropin levels predict live birth outcomes following frozen embryo transfer with and without preimplantation genetic testing for aneuploidy (PGT-A). Fertil Steril 2018;110(4)e209. 

Neal SA, Morin SJ, Tiegs AW, Sun L, Franasiak JM, Kaser DJ, Hong KH, Werner MD, Scott Jr. RT. Repeat biopsy for preimplantation genetic screening (PGS) reanalysis does not adversely impact obstetrical outcomes. Fertil Steril 2018;109(3):e41. 

Tiegs AW, Sun L, Neal SA, Morin SJ, Werner MD, Scott Jr. RT. Worth the wait? Findings from culturing embryos through day 7. Fertil Steril 2018;109(3):e18-19. 

Chattopadhyay R, Neal SA, Juneau CR, Landis J, Morin SJ, Kaser DJ, Scott Jr. RT. The presence of fluid in the endometrial cavity, even when it resolves after progesterone administration, is associated with a higher incidence of preterm birth in frozen embryo transfer cycles. Fertil Steril 2018;109(3):e18-19. 

Chattopadhyay R, Neal SA, Juneau CR, Landis L, Morin SJ, Werner MD, Scott Jr. RT. Empiric antibiotic treatment of suspected chronic endometritis does not improve sustained implantation rates following failed euploid frozen embryo transfer (FET). Fertil Steril 2018;109(3):e19. 

Dougherty MP, Morin SJ, Green KA, Franasiak JM, Neal SA, Tiegs AW, Werner MD, Scott Jr. RT. Sperm DNA fragmentation (SDF) index on day of transvaginal oocyte retrieval (TVOR) does not correlate with the incidence of segmental aneuploidy in blastocysts analyzed with targeted next generation sequencing (NGS). Fertil Steril 2018;109(3):e25-26. 

Morin SJ, Neal SA, Tiegs AW, Scott Jr. RT. Double embryo transfer of a euploid blastocyst after a failed single embryo transfer does not improve live birth rate but significantly increases the risk of twins. Fertil Steril 2018;109(3):e39. 

Neal SA, Forman EJ, Juneau CR, Morin SJ, Sun L, Zimmerman RS, Scott Jr. RT. Rebiopsy and preimplantation genetic screening (PGS) reanalysis for embryos with an initial non-diagnostic result yields a euploid result in the majority of cases. Fertil Steril 2017;108(3):e276. 

Neal SA, Forman EJ, Juneau CR, Molinaro TA, Morin SJ, Sun L, Zimmerman RS, Scott RT. Repeat biopsy of cryopreserved embryos for preimplantation genetic screening (PGS) reanalysis does not adversely impact reproductive potential. Fertil Steril 2017;108(3):e276-277. 

Goodman LR, Khan Z, Franasiak JM, Juneau CR, Morin SJ, Neal SA, Scott Jr. RT, Goldberg JM. Current surgical experience and deficits in reproductive endocrinology and infertility training across fellowships in the United States. Fertil Steril 2017;108(3):e210. 

Juneau CR, Marin D, Scott K, Morin SJ, Neal SA, Juneau J, Scott, Jr. RT. CAREs trial (celiac disease and reproductive effects): a gluten-free diet does not impact IVF outcomes. Fertil Steril 2017;108(3):e257. 

Morin SJ, Juneau CR, Neal SA, Scott, Jr. RT, Hotaling JM. Total motile sperm count is negatively correlated with fertilization rate but not blastulation, euploidy, or implantation in ICSI cycles. Fertil Steril 2017;108(3):e127. 

Morin SJ, Juneau CR, Neal SA, Landis JN, Scott, Jr. RT, Hotaling JM. Comparison of the relative efficiency of ICSI and extended culture with epididymal sperm versus testicular sperm in patients with obstructive azoospermia. Fertil Steril 2017;108(3):e6. 

Franasiak JM, Hong KH, Werner MD, Juneau CR, Morin SJ, Neal SA, Molinaro TA, Scott, Jr. RT. Preimplantation genetic screening (PGS) in low responders shortens time to pregnancy: a randomized controlled trial. Fertil Steril 2017;108(3):e60-61. 

Morin SJ, Juneau CR, Neal SA, Scott, Jr. RT, Forman EJ. Elimination of a policy of empiric antibiotic therapy for male patients prior to collection for IVF results in no diminution in fertilization rate. Fertil Steril 2017;108(3):e148. 

Morin SJ, Patounakis G, Juneau CR, Neal SA, Scott, Jr. RT, Seli E. Quantity versus quality: do patients with diminished ovarian reserve (DOR) and poor response to stimulation also exhibit poor blastulation and increased aneuploidy? Fertil Steril 2017;108(3):e49. 

Juneau CR, Marin D, Scott K, Morin SJ, Neal SA, Juneau J, Scott, Jr. RT. CAREs trial (celiac disease and reproductive effects): celiac disease is not more common in patients undergoing IVF and outcomes are not compromised in affected patients. Fertil Steril 2017;108(3):e33-34. 

Morin SJ, Kaser DJ, Juneau CR, Neal SA, Upham K, Tao X, Zhan Y, Scott, Jr. RT. The LO2 trial, phase I: a paired randomized controlled trial (RCT) comparing blastulation rate in ultra-low (2%) vs. low 95%) oxygen in extended culture (EC). Fertil Steril 2017;108(3):e58-59. 

Tiegs AW, Morin SJ, Forman EJ, Franasiak JM, Zimmerman RS, Zhan R, Juneau CR, Neal SA, Scott, Jr. RT. Only segmental or mosaic embryos available for transfer: a rare phenomenon in preimplantation genetic screening (PGS) cycles using targeted next generation sequencing (NGS). Fertil Steril 2017;108(3):e273-274. 

Kim JG, Juneau CR, Morin SJ, Neal SA, Franasiak JM, Patounakis G, Scott, Jr. RT. ABC trial (assessment of body content): body composition in couples undergoing IVF predicts outcomes when body mass index alone does not. Fertil Steril 2017;108(3):e103. 

Neal S, Landis J, Juneau C, Morin S, Scott R. Pregnancy outcomes following conversion to vaginal estradiol for endometrial hypoproliferation in frozen embryo transfer cycles. Fertil Steril 2017;107(3):e25-26. 

Dougherty M, Morin S, Juneau C, Neal S, Scott R. Fewer than 9 days of estrogen exposure prior to progesterone initiation results in lower pregnancy rates in programmed frozen embryo transfer cycles. Fertil Steril 2017;107(3):e11-12. 

Kim J, Juneau C, Landis J, Morin S, Neal S, Scott R. ABC Trial: Appraisal of Body Content. How percent body fat compares to body mass index in evaluating infertile couples. Fertil Steril 2017;107(3):e39-40. 

Chattopadhyay R, Juneau C, Landis J, Morin S, Neal S, Scott R. Persistent fluid in the endometrial cavity that resolves after progesterone administration prior to transfer does not impact live birth rate. Fertil Steril 2017;107(3):e11. 

Juneau C, Marin D, Scott K, Morin, S, Neal S, Scott R. CAREs trial and reproductive effects. Fertil Steril 2017;107(3):e6-7. 

S. Neal, S. J. Morin, J. M. Franasiak, C. R. Juneau, Y. Zhan, R. T. Scott Jr. Single embryo transfer (SET) following comprehensive chromosome screening (CCS) is more cost-effective than unscreened sequential SET. Fertil Steril 2016;106(3):e19. 

C. R. Juneau, K. Scott, S. Neal, S. J. Morin, Y. Zhan, R. S. Zimmerman, N. Treff, J. M. Franasiak, R. T. Scott. Reliable detection of segmental aneuploidy identified by next generation sequencing (NGS). Fertil Steril 2016;106(3):e377. 

S. A. Neal, W. S. Graybill, E. Garrett-Mayer, C. H. Watson, M. L. McDowell, V. E. McLean, W. T. Creasman. Lymph-vascular space invasion in uterine corpus cancer: what is its prognostic significance in the absence of lymph node metastases? Gynecologic Oncology 2015;137 Suppl 2:91. 

Neal SA, Franasiak JM, Forman EJ, Werner MD, Taylor D, Treff NT, Scott, Jr. RT. High cellularity of trophectoderm biopsy adversely affects pregnancy outcomes. Fertil Steril 2014;102(3):e19. 

Treff NR, Forman EJ, Neal SA, Scott, Jr. RT. Routinely distinguishing normal and balanced translocation carrier embryos using SNP arrays. Fertil Steril 2014;102(3):e181. 

Werner MD, Forman EJ, Hong KH, Franasiak JM, Neal SA, Scott, Jr. RT. Dual trigger with GnRH agonist (GnRHa) and varying doses of hcg increases blastulation rate amongst high responders. Fertil Steril 2014;102(3):e220-221. 

Addison S, Shi X, Schwartz TA, Kraus VB, Stabler T, Helmick CG, et al. Selenium and biomarkers of joint tissue metabolism in a community-based cohort: The Johnston County Osteoarthritis Project. Arthritis Rheum 2009;60 Suppl 10:223. 

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